The design of Lightning Pearls reflects a unique approach to the difficult and recalcitrant problem of chronic inflammatory disease. It is based on the Qing dynasty remedy Jiajian Su He Tang (Perilla and Mint Decoction Modified), and represents a time-honored solution for the important clinical phenomenon of “Brain Gu Syndrome”: treatment resistant diseases caused by infections of the nervous system. Lightning Pearls aims to not only counteract pathogens, but also to treat terrain issues associated with various deficiencies in the patient’s qi, yin, and blood. Lightning Pearls can be considered to be a more constitutional and long-term version of the Fever School’s flagship remedy Yin Qiao San (Honeysuckle and Forsythia Powder), and is thus also suitable to treat external invasions, or for preventing them during air travel.